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The molecular basis of PDGF-D signaling in immune cells
Investigating the molecular basis of PDGF-D signaling in immune cells.
Dr Alexander David Barrow
(03) 9035 6297 | alexanderdav@unimelb.edu.au
- Position:
- Laboratory Head
- Theme(s):
- Immunology, Viral Infectious Diseases, Bacterial and Parasitic Infections
- Discipline(s):
- Discovery Research, Clinical and health systems research
- Unit(s):
- The University of Melbourne, Department of Microbiology and Immunology (DMI)
- Lab Group(s):
- Barrow group
Dr Alexander Barrow obtained his degree in Microbiology from the University of Leeds and his PhD in immunology from the University of Bristol in the UK. Alex performed his post-doctoral research at the Cambridge Institute for Medical Research (CIMR) and was the recipient of a Marie Curie International Fellowship, which he used to travel to Washington University in St Louis School of Medicine, USA. Alex teaches cancer immunology to undergraduate students and heads a laboratory in the Department of Microbiology and Immunology where his research group examines how growth factors can activate immune responses to cancer cells and pathogens.
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Key Achievements
Publications
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Alex’s research has contributed significantly to defining the ligands for orphan immunoreceptors and how these receptor signal in innate immune cells to evoke functional immune responses. Alex provided the first evidence that natural killer cells have evolved receptors to sense growth factors expressed by cancer cells in order to control tumour growth. Alex’s work is also relevant to infectious disease since many pathogens encode their own growth factors. Alex was the recipient of a prestigious Marie Curie International Fellowship and has published in leading scientific journals, such as Cell, Nature Immunology, Journal of Clinical Investigation and Current Opinion in Immunology.
ProjectsLoading ORCID data…Research Groups-
Barrow group
My lab is interested in how receptors expressed by immune cells distinguish normal healthy cells from malignant cells or pathogens. We want to understand how these receptors work together to regulate immune responses so we can design better clinical interventions.
Lab Team
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Patrick ConstantinescuResearch Officer
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Yuhan SunMasters Student
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Alexander James SedgwickMasters Student
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Stephanie Thuy Dong PhamVisiting Research Scholar
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