Infectious Disease Surveillance and One Health

Cefotaxime Resistant Salmonella enteritidis Serovar

Project Summary

Salmonellosis is an important cause of bacterial gastroenteritis in Australia. Reported rates of antimicrobial resistance in locally-acquired strains of Salmonella enterica serovar Typhimurium are low compared with other countries, with no third-generation cephalosporin resistance reported.  Since 2012, resistance to cefotaxime has been noted in multi-drug resistant (MDR) isolates of S. enterica serovar Typhimurium phage-type 44 (STm44) obtained from humans and food animals in Victoria.

This study aims to characterise the resistance mechanism and investigate the emergence of this non-susceptible strain, using a combination of phenotypic methods and whole-genome sequencing (WGS).

Project Partners

OzFoodNet, ACT, Australia

Department of Health and Human Services, Victoria, Australia

Publications

Emergence of multidrug resistance in locally-acquired human infections with Salmonella Typhimurium in Australia owing to a new clade harbouring blaCTX-M-9.

Sparham SJ, Kwong JC, Valcanis M, Easton M, Trott DJ, Seemann T, Stinear TP, Howden BP. International Journal of Antimicrobial Agents. 2017;50(1):101-5. doi: 10.1016/j.ijantimicag.2017.02.014