The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: Understanding factors that regulate T cell stemness in cancer and chronic disease

Kallies Group

Cytotoxic T cell immunity in cancer and chronic disease is maintained by stem-like T cells, also termed precursors of exhausted T cells. In this project, we will use novel mouse models and cutting-edge molecular methods to identify mechanisms that regulate the development and heterogeneity of stem-like T cells in the context of disease progression and therapeutic intervention, including checkpoint inhibition and mRNA vaccination. 

Contact project supervisor for further
information and application enquiries

Project Supervisor

Professor Axel Kallies

Project Co-supervisor

Dr Lisa Rausch

Project availability
PhD/MPhil
Master of Biomedical Science
Honours

Kallies Group

axelk@unimelb.edu.au

3 vacancies

Themes
Immunology
Viral Infectious Diseases
Bacterial and Parasitic Infections
Cross Cutting Disciplines
Clinical and health systems research

Our group has done pioneering work in understanding the role of immune cells in infection, metabolic diseases and cancer. In particular, our laboratory has discovered key molecules and pathways that regulate the differentiation and function of of T cells, including cytotoxic CD8, CD4 and regulatory T cells in viral infection, cancer and type 2 diabetes.