Project: Understanding factors that regulate T cell stemness in cancer and chronic disease
Kallies Group
Cytotoxic T cell immunity in cancer and chronic disease is maintained by stem-like T cells, also termed precursors of exhausted T cells. In this project, we will use novel mouse models and cutting-edge molecular methods to identify mechanisms that regulate the development and heterogeneity of stem-like T cells in the context of disease progression and therapeutic intervention, including checkpoint inhibition and mRNA vaccination.
Contact project supervisor for further
information and application enquiries
Kallies Group
3 vacancies
Our group has done pioneering work in understanding the role of immune cells in infection, metabolic diseases and cancer. In particular, our laboratory has discovered key molecules and pathways that regulate the differentiation and function of of T cells, including cytotoxic CD8, CD4 and regulatory T cells in viral infection, cancer and type 2 diabetes.
Kallies Group Current Projects
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Dissecting the role of tissue regulatory T cells in the development of memory T cells during infection and cancer.
PhD/MPhil, Master of Biomedical Science, Honours
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Understanding factors that regulate T cell stemness in cancer and chronic disease
PhD/MPhil, Master of Biomedical Science, Honours
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Identifying mechanisms that control maintenance and function of CD4 T cells in cancer
PhD/MPhil, Master of Biomedical Science, Honours
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Understanding how regulatory T cells (Tregs) control cancer and chronic disease
PhD/MPhil, Master of Biomedical Science, Honours
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Understanding the heterogeneity of intestinal resident memory T cells (TRMs) and their role in homeostasis
PhD/MPhil, Master of Biomedical Science, Honours
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Understanding how metabolism and nutrient signaling regulate intestinal tissue resident memory T cells development and function
PhD/MPhil, Master of Biomedical Science, Honours
Research degrees at the Doherty Institute are administered by the University of Melbourne.