The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: Remote virulence: understanding the role of bacterial membrane vesicles and Staphylococcus aureus disease

Stinear Group

Staphylococcus aureus (aka Golden Staph) is a leading cause of lethal bacterial infections. S. aureus produces many virulence factors that can prevent effective immune responses. There is growing evidence that S. aureus can remotely neutralise immune cells by releasing bacterial cellular contents in the form of extracellular membrane vesicles (SaMVs). This project will examine what makes up these SaMVs (e.g. the repertoires of proteins and nucleic acids) to understand how S. aureus can remotely interact with the human immune system and cause persistent and often deadly infections.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Dr Abdou Hachani

Project Co-supervisor

Associate Professor Maria Liaskos

maria.liaskos@unimelb.edu.au

Professor Tim Stinear

Project availability
Master of Biomedical Science
Honours

Stinear Group

tstinear@unimelb.edu.au

2 vacancies

Themes
Antimicrobial Resistance
Bacterial and Parasitic Infections
Cross Cutting Disciplines
Computational Science and Genomics

Our research leverages the latest advances in genomics, cell biology, host-pathogen interactions, molecular biology, computational biology and clinical studies to understand how a major human bacterial pathogen Staphylococcus aureus (aka Golden Staph), causes disease.