Project: Mapping seasonal coronavirus genes that suppress the human innate immune response
Subbarao Group
Seasonal coronaviruses (sCoVs) cause 15-30% of common colds annually. While it is well established that multiple SARS-CoV-2 viral proteins can dampen the host innate immune response, these crucial virus-host interactions have not been examined for sCoVs. This project will use molecular cloning, biological reporter assays and virus infection models to identify the viral genes associated with restriction of innate immune response in human cells.
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Subbarao Group
4 vacancies
Research in the Subbarao laboratory focuses on respiratory viral diseases of global importance including pandemic and seasonal influenza and coronaviruses including SARS-CoV-2 (COVID-19) and human coronaviruses. We study virus biology and pathogenesis, airborne spread of respiratory viruses, immune responses to infection and vaccination, and antiviral drugs. We use state of the art techniques in virology, molecular biology and immunology, including reverse genetics, infection of stem cell derived tissues and studies in animal models.
Subbarao Group Current Projects
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Defining the role of secreted mucins in seasonal human coronavirus infection
Master of Biomedical Science, Honours
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Defining the placental response to virus infection
PhD/MPhil, Master of Biomedical Science
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Using complex in vitro respiratory models and reverse genetics to study seasonal coronaviruses
PhD/MPhil, Master of Biomedical Science, Honours
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Investigating the evolution of seasonal coronaviruses and the effects of these changes on viral replication, neutralisation and receptor binding
PhD/MPhil, Master of Biomedical Science, Honours
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Mapping seasonal coronavirus genes that suppress the human innate immune response
Master of Biomedical Science, Honours
Research degrees at the Doherty Institute are administered by the University of Melbourne.