Project: High-resolution dynamics of Staphylococcus aureus intracellular persistence
Stinear Group
Usually considered an extracellular pathogen, our group and others have shown that Staphylococcus aureus can also be an intracellular pathogen. Living in an intracellular niche enables S. aureus to evade antibiotic treatment and extracellular immune surveillance and help explain why some Staph infections are difficult to eradicate. This project will use a new high-throughput assay developed by our team called InToxSa, combined with genomics and computational approaches to give a molecular-level understanding of S. aureus within different host cell types such as macrophages, osteoblasts, epithelial and endothelial cells. The data from this project will allow us to find the molecular tricks used by the pathogen to cause lethal infections.
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Stinear Group
2 vacancies
![](https://www.doherty.edu.au/uploads/banner_bg_img/Tim_Stinear_1_hr.jpg)
Our research leverages the latest advances in genomics, cell biology, host-pathogen interactions, molecular biology, computational biology and clinical studies to understand how a major human bacterial pathogen Staphylococcus aureus (aka Golden Staph), causes disease.
Stinear Group Current Projects
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High-resolution dynamics of Staphylococcus aureus intracellular persistence
Master of Biomedical Science, Honours
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Remote virulence: understanding the role of bacterial membrane vesicles and Staphylococcus aureus disease
Master of Biomedical Science, Honours