Research Projects

In severe S. aureus infections, bacterial adaptation within the human host can lead to antibiotic treatment failure through the emergence of mutations promoting antibiotic resistance and tolerance. Identifying these mutations might enable more effective treatments targeted to the bacterial strains that carry them. This project will use adaptive laboratory evolution to gather a deeper understanding of why key anti-staphylococcal antibiotics fail in clinical infections. It involves performing adaptive evolution experiments, testing antibiotic resistance phenotypes, bacterial whole-genome sequencing, bioinformatics

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