Healthcare-associated infections and antimicrobial use at a major referral hospital in Papua New Guinea: a point prevalence survey
Authors:
- Curtis, Stephanie J.
- Barnabas, Roland
- Cairns, Kelly A.
- Cameron, Donna
- Coghlan, Benjamin
- Jones, Robert
- Joseph, Jacklyn
- Kali, Alu
- Kep, Dimitri
- Klintworth, Gemma
- Levy, Stephanie
- Mason, Matt
- Norrie, Majella
- Peel, Trisha
- Tamolsaian, Gilam
- Telenge, Josephine
- Tumu, Nellie
- Stewardson, Andrew J.
- Ak, Gabriella
- Thomas, Benjamin
- Maingu, Cassius
- Polly, Dellyne
- Nogua, Hans
- Mondowa, Jessica
- Sokal, Joe
- Yem, Josen
- Lawrence, Joyce
- Rarah, Mathilda
- Olwont, Rose
- Marcus, Rupert
- Silas, Saberina
- Kialo-Davis, Stephanie
- Macintyre, Alison
- Russo, Philip
- Kehoe, Rosaleen
Details:
The Lancet Regional Health - Western Pacific, Volume 48, 2024-07-31
Article Link: Click here
Background Healthcare-associated infections (HAI) and antimicrobial use (AMU) are drivers for antimicrobial resistance, and robust data are required to inform interventions and track changes. We aimed to estimate the prevalence of HAI and AMU at Port Moresby General Hospital (PMGH), the largest hospital in Papua New Guinea. Methods We did a point prevalence survey (PPS) on HAI and AMU at PMGH in May 2023 using the European Centre for Disease Prevention and Control (ECDC) PPS protocol. We included all critical care patients and randomly sampled half of the patients in other acute-care wards. We calculated weighted HAI and AMU prevalence estimates to account for this sampling strategy. Weighted HAI estimates were also calculated for an expanded definition that included physician diagnosis. Findings Of 361 patients surveyed in 18 wards, the ECDC protocol identified 28 HAIs in 26 patients, resulting in a weighted HAI prevalence of 6.7% (95% CI: 4.6, 9.8). Surgical site infections (9/28, 32%) were the most common HAI. When adding physician diagnosis to the ECDC definitions, more skin and soft tissue, respiratory, and bloodstream HAIs were detected, and the weighted HAI prevalence was 12.4% (95% CI: 9.4, 16.3). The prevalence of AMU was 66.5% (95%CI: 61.3, 71.2), and 73.2% (263/359) of antibiotics were from the World Health Organization Access group. Interpretation This is the first reported hospital PPS of HAI and AMU in Papua New Guinea. These results can be used to prioritise interventions, and as a baseline against which future point prevalence surveys can be compared. Funding Australian Government Department of Foreign Affairs and Trade and Therapeutic Guidelines Limited Australia.