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SARS-CoV-2 mouse adaptation selects virulence mutations that cause TNF-driven age-dependent severe disease with human correlates


Author(s):

Stefanie M. Bader, James P. Cooney, Dylan Sheerin, George Taiaroa, Leigh Harty, Kathryn C. Davidson, Liana Mackiewicz, Merle Dayton, Stephen Wilcox, Lachlan Whitehead, Kelly L. Rogers, Smitha Rose Georgy, Anna K. Coussens, Samantha L. Grimley, Vincent Corbin, Miranda Pitt, Lachlan Coin, Raelene Pickering, Merlin Thomas, Cody C. Allison, Julie McAuley, Damian F.J. Purcell, Marcel Doerflinger, Marc Pellegrini

Details:

Proceedings of the National Academy of Sciences of the United States of America, Volume 120, Issue 32, 2023-08-08, Article number e2301689120

Article Link: Click here

Affiliations:

  • Faculty of Science
  • The Peter Doherty Institute for Infection and Immunity
  • Walter and Eliza Hall Institute of Medical Research
  • University of Melbourne
  • Faculty of Medicine, Nursing and Health Sciences
  • Royal Melbourne Hospital

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We are committed to collaboration with Aboriginal and Torres Strait Islander communities to reduce the unacceptable burden of infectious disease. We are committed to training the next generation of exceptional Indigenous leaders in infection and immunity.

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